| 货号: 26001-1 |
| 描述: Anti-cGMP Mouse Monoclonal Antibody |
| 背景介绍: cGMP is a ubiquitous second messenger mediating cellular responses to various exogenous and endogenous signaling molecules. cGMP regulates physiological processes by activating protein kinases, gating specific ion channels, and modulating cellular cyclic nucleotide concentrations through phosphodiesterases. The conversion of GTP to cGMP is catalyzed by guanylyl cyclases (GCs). There are two types of GCs in mammals: the soluble and the membrane-bound GCs. The soluble GCs are generally activated when nitric oxide binds to the attached prosthetic heme group. Seven membrane-bound GCs (also named transmembrane or particulated GCs) have been identified in the human genome. GC-A and GC-B are natriuretic peptide receptors. GC-C can be activated by bacterial heat-stable enterotoxins, guanylin and uroguanylin. The activity of transmembrane GCs can also be modulated by other receptor signals through intracellular signaling pathways. |
| 免疫原: cGMP |
| 经过测试的应用: ELISA, WB, IHC |
| 推荐稀释比: ELISA 1:1000-1:5000 WB 1:500-1:2000 |
| 浓度: 1 mg/ml |
| 宿主: Mouse |
| 形式: Liquid |
| 克隆性: Monoclonal |
| 亚型: IgG |
| 纯度: Purified from ascites |
| 防腐剂: No |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| 储存条件: Store at -20°C. Avoid repeated freezing and thawing |
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